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When drug therapy goes wrong

Stingl illustrated this using the example of phenoconversion. This is what it is called when a drug-metabolizing enzyme, which actually functions normally in a patient, is overloaded by being stressed by several drugs and ultimately only works slowly. A drug that is broken down by this enzyme and which the patient has tolerated in the normal intestinal dosage without comedication can then cause side effects under appropriate comedication at the same dosage.